Not only embryo quality but also Endometrial Thickness Contributes to IVF outcome: a retrospective study of all IVF cycles in Yasmin Clinic, Jakarta, Indonesia

Abstract

Objective: To study the endometrial thickness and embryo quality during In Vitro Fertilization (IVF) cycles in predicting IVF outcome. Methods: This retrospective study involved 206 infertile patients undergoing 218 IVF cycles in Yasmin Clinic, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia. All IVF cycles were performed from January 2005 until May 2009. The outcome of this study is the clinical pregnancy following IVF cycles. The endometrial thickness was measured on the day of human chorionic gonadotrophin (hCG) administration. The number of embryos that developed ≥ 8 cells on cleavage II represented as the embryo quality. Results: There were 51 among 218 cycles (23.4%) resulted in pregnancy. The endometrial thickness on day of hCG administration was significantly higher in pregnant group compared to non-pregnant group (11.49±1.97 mm versus 10.13±1.93mm; p<0.0001). The number of embryos with ≥ 8 cells on cleavage II was higher in pregnant group than non-pregnant group {3 embryos (1-11) versus 1 embryos (0-11); p<0.0001}. From the ROC curve, the endometrial thickness cut-off value ≥ 10.95 mm was the best value to predict pregnancy outcome. This value had 64.7% sensitivity, 62.3% specificity, 34.4% positive predictive value, and 85.2% negative predictive value. Conclusion: Both embryo quality and endometrial thickness significantly have contribution to IVF outcome prediction. [Indones J Obstet Gynecol 2010; 34-1:39-42] Keywords: IVF cycles, endometrial thickness, embryo quality