Creatinine clearance levels are associated with the incidence of preeclampsia

Hubungan Creatinine Clearance Dengan Kejadian Preeklampsia

  • Jesslyn M Sanusi Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D Kandou Central General Hospital Manado
  • Hermie M. M. Tendean Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D Kandou Central General Hospital Manado
  • Juneke J. Kaeng Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D Kandou Central General Hospital Manado

Abstract

Abstract
Objective: Determine thecorrelation between creatinine clearance relationship with preeclampsia incidence.
Method: Cross sectional research.
Result: Creatinine clearance examination conducted on 60 sample of pregnant women > 20 weeks,30 normotensive samples and 30 preeclampsia samples. The obtained data analyzed using SPSS software version 22.0 and discussed using the existing literature theory.
Creatinine clearance average level in normotensive pregnancy 124.650 ± 14.3699ml/minutes/1,73m2and preeclampsia 74.003 ± 23.169ml/minutes/1,73m2. After Mann-Whitney statistical test obtained p value = 0,000. From ROC curve analysis for creatinine clearance obtained sensitivityvalue 100% and specificity 99,53%.
Conclusion:There is a significant correlation between the creatinine clearance levels with preeclampsia.
Keywords: creatinine clearance, normotensive, preeclampsia.
 
Abstrak
Tujuan: Menentukan hubungan antara creatinine clearance dengan kejadian preeklamsia.
Metode: Penelitian potong lintang.
Hasil:Dilakukan pemeriksaan creatinine clearance pada 60 sampel ibuhamil > 20 minggu, 30 sampel darah normal dan 30 sampel preeklamsia. Data yang diperoleh dianalisa dengan menggunakan software SPSS versi 22.0 dan dibahas dengan menggunakan  teori literatur yang ada.
Kadar rerata creatinine clearance pada kehamilan normotensi 124,650 ± 14,3699 ml / menit / 1,73m2 dan preeklampsia 74,003 ± 23,169 ml / menit / 1,73m2. Setelah uji statistik Mann-Whitney diperoleh nilai p = 0,000. Dari analisis kurva ROC untuk creatinine clearance diperoleh nilai sensitivitas 100% dan spesifisitas 99,53%.
Kesimpulan: Ada hubungan yang signifikan  antara creatinine clearance dengan kejadian preeklamsia.
Kata kunci: creatinine clearance, normotensi, preeklampsia.

Author Biographies

Hermie M. M. Tendean, Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D Kandou Central General Hospital Manado
Departement of Obstetrics and Gynecology
Juneke J. Kaeng, Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D Kandou Central General Hospital Manado
Departement of Obstetrics and Gynecology
Published
2018-10-12
How to Cite
SANUSI, Jesslyn M; TENDEAN, Hermie M. M.; KAENG, Juneke J.. Creatinine clearance levels are associated with the incidence of preeclampsia. Indonesian Journal of Obstetrics and Gynecology, [S.l.], p. 213 - 217, oct. 2018. ISSN 2338-7335. Available at: <http://inajog.com/index.php/journal/article/view/843>. Date accessed: 12 nov. 2018. doi: https://doi.org/10.32771/inajog.v6i4.843.
Section
Research Article