A1298C Polymorphism of Fetal Methylenetetrahydrofolate Reductase (MTHFR) Gene as a Risk Factor for Spontaneous Abortion

Abstract

Objective: To investigate the role of A1298C polymorphism of fetal methylenetetrahydrofolate reductase (MTHFR) gene in spontaneous abortion. Method: The case control study design recruited 96 subjects in Siti Fatimah and Pertiwi mother and child hospital, Dr. Wahidin Sudirohusodo, Pelamonia, Bhayangkara, Syekh Yusuf, Haji and Labuang Baji hospital from March to September 2014. All subjects fulfilling the inclusion criteria were taken tissue samples from mothers experiencing spontaneous abortion and blood samples from normally born baby. The data were analyzed using Pearson chi-square with significant rate of 5% (p<0.05). Result: There were 49 samples as case group consisting of 36 samples (62.1%) with mutant genotype of MTHFR gene (1298AC + 1298CC) paired with 22 samples (37.9%) for the control group and also 13 samples (34.2%) with normal genotype gene (1298AA) from case group paired with 25 samples (65.8%) from control group. Conclusion: A1298C polymorphism of fetal MTHFR gene has correlation to the rate of spontaneous fetal abortion. [Indones J Obstet Gynecol 2016; 4-2: 67-69] Keywords: A1298C polymorphism, spontaneous fetal abortion