BRCA1 Gene Q356R (1186A=G) Polymorphism and Epithelial Ovarian Cancer Incidence

  • Benyamin Rakhmatsyah Faculty of Medicine Sriwijaya University/ Dr. Mohammad Hoesin General Hospital Palembang
  • Agustria Z Saleh Faculty of Medicine Sriwijaya University/ Dr. Mohammad Hoesin General Hospital Palembang
  • Rizal Sanif Faculty of Medicine Sriwijaya University/ Dr. Mohammad Hoesin General Hospital Palembang
  • Yuwono Yuwono Faculty of Medicine Sriwijaya University/Dr. Mohammad Hoesin General HospitalPalembang

Abstract

Objective: To determine the association between BRCA1 gene Q356R (1186A=G) polymorphism and epithelial ovarian cancer incidence. Methods: This study is an observational analytic study with casecontrol study design. All patients diagnosed with epithelial ovarian cancer that were treated in the outpatient clinic and inpatient ward of the Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin Hospital, Palembang who met the inclusion criteria were included in this study. DNA extraction was performed on blood samples, followed by PCR-RFLP process. Results: We obtained the genotype distribution of BRCA1 Q356R (1186A=G) polymorphisms to be QQ genotype (wild-type) on all 50 subjects in the case group (100%) and 50 control subjects (100%). Similarly, all BRCA1 alleles have the Q allele. The results of this study found no polymorphism of the BRCA1 Q356R (1186A=G) in the ovarian cancer and control groups. Conclusion: Polymorphism of BRCA1 gene Q356R (1186A=G) was not significantly associated with epithelial ovarian cancer incidence. [Indones J Obstet Gynecol 2015; 3-4: 206-211] Keywords: BRCA1 gene, epithelial ovarian cancer, polymorphism

Downloads

Download data is not yet available.

Author Biographies

Benyamin Rakhmatsyah, Faculty of Medicine Sriwijaya University/ Dr. Mohammad Hoesin General Hospital Palembang
Department of Obstetrics and Gynecology
Agustria Z Saleh, Faculty of Medicine Sriwijaya University/ Dr. Mohammad Hoesin General Hospital Palembang
Department of Obstetrics and Gynecolog
Rizal Sanif, Faculty of Medicine Sriwijaya University/ Dr. Mohammad Hoesin General Hospital Palembang
Department of Obstetrics and Gynecolog
Yuwono Yuwono, Faculty of Medicine Sriwijaya University/Dr. Mohammad Hoesin General HospitalPalembang

Department of Clinical Microbiology and Biomolecular Medicine

Published
2015-10-14
Section
Research Article