Maternal Serum Interleukin6 Level in Correlation with Preterm Delivery

Abstract

Objective: To determine the correlation between maternal serum Interleukin-6 (IL-6) serum level with preterm delivery. Methods: We performed an observational cross-sectional study of 30 pregnant women between 21 to 36 week gestational age with and wthout labour (delivery) in Prof. Dr. RD. Kandou Hospital Manado. Samples were collected with consecutive sampling method. Data was analyzed using Mann-Whitney test with significance level of p<0.05. Results: We encountered 15 preterm pregnancy and 15 preterm delivery, 6 (40%) cases belonged to the age group <20 years old. Incidence of preterm delivery with history of preterm delivery in a previous pregnancy was 6 cases (40%). This study found that the mean maternal serum IL-6 level in preterm delivery was 12.9 pg/ml, which was higher than preterm pregnancy (2.14 pg/ml). Conclusion: There is significant correlation between maternal IL-6 serum level with preterm delivery which was higher at 4.55-38.87 pg/ml than women with preterm pregnancy (1.5-3.07 pg/ml). [Indones J Obstet Gynecol 2015; 3-4: 185-189] Keywords: Interleukin-6 level, maternal serum, preterm delivery, preterm pregnancy