The Level of Ca125 in Preand Postoperative of Endometriosis

Abstract

Objective: To determine the Ca-125 level in pre- and post-operative of endometriosis and its correlation to endometriosis stage and severity of dysmenorrhea. Method: This was a cross-sectional study design conducted at Dr. Wahidin Sudirohusodo dan some affiliated hospitals. We took the patients undergoing laparoscopy or laparotomy consecutively. Result: The mean value of preoperative Ca-125 level in stage I-II was 21.53 (SD 12.64) IU/ml vs 72.52 (SD 8.52) IU/ml in stage III-IV. The mean value of postoperative Ca-125 level was 14.82 (SD 10.00) IU/ml (stage I-II) vs 61.03 (SD 8.43) IU/ml (stage III-IV); they were significantly different (p<0.001). There was a significant correlation between Ca-125 level and the stage of endometriosis (r=0.43 and 0.52; p=0.005). We observed mild to severe dysmenorrhea for stage I-II; while, patients had moderate to severe dysmenorrhea in stage III-IV (p<0.001) and both of them showed a significant correlation (r=0.318 and 0.537; p<0.05). The Ca-125 level in stage I-II endometriosis was lower than stage III-IV. Conclusion: Level of Ca-125 will decrease after endometriosis surgery. There is a strong correlation between preoperative level of Ca-125 and endometriosis stage. The severity of dysmenorrhea has the correlation to the stage of endometriosis. Keywords: Ca-125, dysmenorrhea, endometriosis