The Role of Vitamin D in Pregnant Women in Birth Weight of Neonates

Peran Vitamin D pada Ibu Hamil terhadap Berat Badan Lahir Neonatus

Abstract

Objective: To determine the relationship between serum
vitamin D levels in third trimester mothers and newborn
birthttweight.
Method: The study was conducted at the maternity ward
of Dr. Zainoel Abidin General Hospital in Banda Aceh,
Indonesia. Maternal and infant serum vitamin D levels
were measured using the Automatic Chemiluminescence
Immunoassay Analyzer (CLIA) method. Blood samples were
collected from mothers in the third trimester and from
infants after delivery. Spearman's correlation rank test was
employed with a confi dence level of 95%. Vitamin D levels
were categorized as suffi cient, insuffi cient, and defi cient.
Results: A total of 39 pregnant women with an average
age of 30.38 ± 6.21 years participated in the study, with a
predominance of 38-39 weeks of gestation (35.9%). The
mean vitamin D levels in mothers and neonates were 17.4
ng/mL and 17.6 ng/mL, respectively (p = 0.003, R = 0.462).
The average birth weight of the babies was 3,100 grams,
ranging from 2,100 grams to 4,200 grams (p = 0.185, R =
0.217). Both variables showed a positive correlation with
varying strength of the relationship.
Conclusion: Maternal serum vitamin D levels in the third
trimester exhibited a positive correlation with serum vitamin
D levels in neonates with moderate strength, but there
was no correlation with birth weight. The evaluation of
maternal third-trimester serum vitamin D levels can serve as
a predictor of neonatal vitamin D levels.
Keywords: birth weight, neonates, pregnancy, vitamin D.

Abstrak
Tujuan: Untuk menilai pengaruh hubungan kadar vitamin
D serum ibu trimester ketiga terhadap kadar vitamin D dan
berat badan neonatus yang dilahirkan.
Metode: Penelitian ini studi observasional korelatif dengan
desain potong lintang yang dilakukan pada kamar bersalin
RSUD dr. Zainoel Abidin Banda Aceh. Pengukuran kadar
vitamin D serum ibu dan bayi dilakukan dengan metode
Automatic Chemiluminescence Immunoassay Analyzer
(CLIA). Analisis data dengan melakukan Uji Spearman’s
correlation rank test untuk menilai kekuatan hubungan dua
variabel.
Hasil: Sebanyak 39 ibu hamil usia 30,38 ± 6,21 tahun terlibat
dalam penelitian ini dengan dominasi usia kehamilan 38–39
minggu (35,9%). Rerata kadar vitamin D ibu dan bayi secara
berurutan adalah 17,4 ng/mL dan 17,6 ng/mL (p = 0,003,
R = 0,462). Rerata berat badan bayi yang dilahirkan adalah
sebesar 3.100 gram dengan rentang 2.100 gram hingga
4.200 gram (p = 0,185, R = 0,217). Kedua variabel didapatkan
korelasi positif dengan kekuatan hubungan bervariasi.
Kesimpulan: Kadar vitamin D serum ibu trimester ketiga
berkorelasi positif terhadap kadar vitamin D serum neonatus
yang dilahirkan dengan kekuatan sedang namun tidak
berkorelasi terhadap berat badan lahir bayi. Kadar vitamin
D serum ibu pada trimester ketiga dapat dijadikan prediktor
kadar vitamin D neonatus saat dilahirkan.
Kata kunci: berat badan lahir, kehamilan, neonatus,
vitamin D.