Roma Index and Adnex Model: which is more Superior in Predicting Epithelial Ovarian Malignancy?

Index Roma dan Model Adnex: Manakah yang Lebih Unggul dalam Memprediksi Keganasan Ovarium Epitelial?

Abstract

Objective: To compare the accuracy of ROMA index and
ADNEX model in predicting the risk of malignancy in ovarian
tumour.
Methods: This was a prospective analytic study. A total of 37
samples were acquired from women of all ages diagnosed
with an ovarian cystic tumour in the Central General Hospital
Prof. Dr. R. D. Kandou. A CA-125 marker, HE4 marker,
menopausal status and ultrasonography (USG) examination
were obtained, and subsequently compared with the fi nal
histopathological results. The data were analysed by using
the SPSS statistics software.
Results: Thirty-seven women participated in this study. The
mean age of participants was 43 years old. The Area Under
Curve (AUC) of the ADNEX was 0.979 with a sensitivity of
90.0%, specifi city of 88.2%, negative predictive value of
89.8%, and positive predictive value of 80.5%. The AUC of
the ROMA model was 0.734 with the sensitivity, specifi city,
negative predictive value, and positive predictive value of
65.0%, 64.7%, 64.8%, and 64.8%, respectively. Both models
showed AUC values > 0.50 (p-value < 0.05).
Conclusions: The IOTA ADNEX had better accuracy than the
ROMA model in predicting ovarian epithelial malignancy.
The ADNEX model had higher sensitivity and specifi city than
the ROMA model.
Keywords: ADNEX, CA-125, HE4, Ovarian tumour, ROMA

Abstrak
Tujuan: Untuk membandingkan akurasi indeks ROMA
dan ADNEX model dalam memprediksi keganasan tumor
ovarium
Metode: Penelitian ini merupakan studi analitik prospektif.
Total 37 sampel penelitian didapatkan dari wanita yang
didiagnosa tumor ovarium kistik di RSUP Prof. Dr. R. D.
Kandou. CA-125, HE4, status menopause dan pemeriksaan
USG dilakukan, dan dibandingkan dengan hasil histopatologi.
Data kemudian dianalisa menggunakan program statistik
SPSS.
Hasil: Tiga puluh tujuh perempuan yang berpartisipasi
dalam penelitian ini. Dengan rerata usia 43 tahun. Total
Area Under Curve (AUC) dari IOTA ADNEX adalah 0,979
dengan sensitivitas 90,0%, spesifi sitas 88,2%, nilai prediksi
negatif 89,8%, dan nilai prediksi positif 80,5%. AUC dari
model ROMA adalah 0,734 dengan sensitivitas, spesifi sitas,
nilai prediktif negatif dan nilai predikitif positif 65.0%, 64.7%,
64.8%, dan 64.8% berturut-turut. Kedua model menunjukkan
nilai AUC > 0,50 (nilai p <0,05).
Kesimpulan: IOTA ADNEX memiliki akurasi yang lebih baik
dibandingkan model ROMA dalam memprediksi keganasan
ovarium epithelial. ADNEX model memiliki sensitivitas dan
spesifi sitas lebih tinggi dibandingkan model ROMA
Kata kunci: ADNEX, CA-125, HE4, ROMA, Tumor Ovarium.