Ovarian Reservation in Women with Ovarian Endometriosis Cyst after Laparoscopic Cystectomy and Leuprorelin Acetate

Abstract

Objective : To determine differences in ovarian reserve in women with ovarian endometrial cysts after laparoscopic cystectomy and injection of leuprorelin acetate

Methods : Single cohort prospective pre and post-test design study with 25 research subjects. The independent variables were interventional laparoscopic cystectomy, and injection of leuprorelin acetate. The dependent variable is ovarian reserve as measured by AMH levels.

Results: The research subjects had a mean age of 31 years and a BMI of 23.55 kg/m2. There were 8 subjects with unilateral cysts, 17 subjects with bilateral cysts. Preoperative AMH levels had a median value of 1.32 ng/mL (0.88-5.13), postoperative AMH levels had a median value of 1.07 ng/mL (0.60-4.53), and postoperative AMH levels + Leuprorelin Acetate injection had a median value of 1.06 ng/mL (0.50-4.65). There was a significant difference between preoperative AMH and postoperative AMH (p<0.001). There was no significant difference between postoperative AMH and postoperative AMH + Leuprorelin Acetate injection (p=0.149). BMI has a relationship (p=0.048) with pre-operative AMH levels with a weak and opposite relationship (r= -0.399).

Conclusion : There was a decrease of 18.9% between pre-operative AMH levels and post-operative AMH levels statistically significant. There is a relationship between BMI and pre-operative AMH levels

Keywords: anti-mullerian hormone, ovarian reserve, leuprorelin acetate, ovarian cystectomy