Effect of Pyridoxine on Prostaglandin Plasma Level for Primary Dysmenorrheal Treatment

Pengaruh Pemberian Piridoksin terhadap Kadar Prostaglandin Plasma sebagai Terapi Dismenore Primer

  • Ervan J Randabunga Faculty of Medicine Universitas Hasanuddin Makassar
  • Efendi Lukas Faculty of Medicine Universitas Hasanuddin Makassar
  • Josephine L Tumedia Faculty of Medicine Universitas Hasanuddin Makassar
  • St. Maisuri T. Chalid Faculty of Medicine Universitas Hasanuddin Makassar

Abstract

Objective : To determine the effect of vitamin B6 (pyridoxine) the levels of prostaglandins and intensity of pain in primary dysmenorrheal.
Methods : The levels of prostaglandin (PGF2α) in plasma measured by ELISA and pain intensity by verbal rating scales conducted on 35 women with primary dysmenorrheal (n=35) supplemented with vitamin B6 100mg for 4 days and controls with placebo (n=35).
Results : Prostaglandin levels decreased significantly after vitamin B6 supplementation (2212.9+1374.2 vs 1490.3+1119.0; p<0.05) followed by a significant reduction in pain intensity (4.29+0.7 vs 1.71+0.5; p<0.05) in the test group compared to control.
Conclusion : Due to vitamin B6 effects on decreasing prostaglandin levels and pain of primary dysmenorrheal, so that B6 vitamin can become the treatment for the primary dysmenorrheal.
Keywords : Primary dysmenorrheal, pyridoxine, prostaglandin
 
Tujuan: Untuk mengetahui pengaruh pemberian vitamin B6 (piridoksin) terhadap kadar prostaglandin dan intensitas nyeri pada dismenore primer.
Metode: Pemeriksaan kadar prostaglandin (PGF2α) dengan ELISA dan pengukuran intensitas nyeri dengan verbal rating scales dilakukan pada 35 orang (n=35) wanita dengan dismenore primer yang mendapatkan vitamin B6 100mg selama 4 hari dan kontrol yang mendapatkan plasebo (n=35).
Hasil: Kadar prostaglandin menurun bermakna setelah pemberian vitamin B6 (2212,9+1374,2 vs 1490,3+1119,0; p<0,05) disertai dengan penurunan intensitas nyeri yang bermakna (4,29+0,7 vs 1,71+0,5; p<0,05) pada kelompok uji dibandingkan kontrol.
Kesimpulan: Vitamin B6 menurunkan kadar prostaglandin dan nyeri sehingga vitamin B6 dapat dipertimbangkan menjadi salah satu pengobatan dismenore primer.
Kata kunci : Dismenore primer, piridoksin, prostaglandin

Author Biographies

Efendi Lukas, Faculty of Medicine Universitas Hasanuddin Makassar
Departement of Obstetrics and Gynecology
Josephine L Tumedia, Faculty of Medicine Universitas Hasanuddin Makassar
Departement of Obstetrics and Gynecology
St. Maisuri T. Chalid, Faculty of Medicine Universitas Hasanuddin Makassar
Departement of Obstetrics and Gynecology
Published
2018-10-15
How to Cite
RANDABUNGA, Ervan J et al. Effect of Pyridoxine on Prostaglandin Plasma Level for Primary Dysmenorrheal Treatment. Indonesian Journal of Obstetrics and Gynecology, [S.l.], p. 239 - 242, oct. 2018. ISSN 2338-7335. Available at: <http://inajog.com/index.php/journal/article/view/848>. Date accessed: 12 nov. 2018. doi: https://doi.org/10.32771/inajog.v6i4.848.
Section
Research Article