Concordance of Human Papillomavirus Type 16 and 18 in Cervical and Oral Specimen of Cervical Cancer Patients

Perbandingan Tingkat Kesesuaian Hasil Identifikasi Human Papilomavirus Tipe 16 dan 18 antara Spesimen Serviks dan Oral pada Penderita Kanker Serviks

  • Willy Akbar Faculty of Medicine Universitas Hasanuddin
  • Syahrul Rauf Faculty of Medicine Universitas Hasanuddin
  • Deviana S. Riu Faculty of Medicine Universitas Hasanuddin
  • St. Maisuri T. Chalid Faculty of Medicine Universitas Hasanuddin

Abstract

Abstract
Objective : To determine the conformity of HPV type 16 and 18 in cervical and oral/buccal specimens from cervical cancer patients.
Methods :A cross-sectional study was conducted in March - September 2016 at several hospitals in Makassar. HPV 16 and 18 genotyping in cervical and oral fluid of 77 patients with cervical cancer performed with PCR method.
Results : The prevalence of HPV type 18 infection both in the cervical and the oral fluid was higher than HPV type 16 [9(47.4%) vs 5(26.3%)]. The aggreement of HPV type 18 infection (r=0.328;p=0.000) in the cervical-oral sites was higher than HPV type 16 (r=0.194;p=0.042).
Conclusion : HPV type 16 and 18 could infect both cervix and oral cavity although type-specific concordance is low.
Keywords :Human papillomavirus,servix, oral cavity
 
Abstrak
Tujuan: Mengetahui tingkat kesesuaian hasil pemeriksaan HPV tipe 16 dan 18 antara spesimen serviks dan oral/buccal pada penderita kanker serviks.
Metode: Penelitian cross sectional ini dilakukan pada Maret – September 2016 pada beberapa rumah sakit di Makassar. Pemeriksaan HPV 16 dan 18 pada cairan serviks dan oral dari 77 orang penderita kanker serviks menggunakan teknik PCR.
Hasil: Prevalensi infeksi bersama pada serviks dan oral HPV tipe 18 lebih tinggi dibandingkan HPV tipe 16 [9(47,4%) vs 5(26,3%)]. Tingkat kesesuaian antara HPV tipe 18 (r=0,328;p=0,000) pada serviks dan oral lebih tinggi dibandingkan tipe 16 (r=0,194;p=0,042).
Kesimpulan: HPV tipe 16 dan 18 dapat menginfeksi serviks dan oral meskipun tingkat kesesuaian kedua tipe ini lemah.
Kata kunci : Human papillomavirus, serviks, kavum oral

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Author Biographies

Syahrul Rauf, Faculty of Medicine Universitas Hasanuddin
Department of Obstetrics and Gynecology
Deviana S. Riu, Faculty of Medicine Universitas Hasanuddin
Department of Obstetrics and Gynecology
St. Maisuri T. Chalid, Faculty of Medicine Universitas Hasanuddin
Department of Obstetrics and Gynecology
Published
2019-01-21
How to Cite
AKBAR, Willy et al. Concordance of Human Papillomavirus Type 16 and 18 in Cervical and Oral Specimen of Cervical Cancer Patients. Indonesian Journal of Obstetrics and Gynecology, [S.l.], p. 69 - 73, jan. 2019. ISSN 2338-7335. Available at: <http://inajog.com/index.php/journal/article/view/817>. Date accessed: 22 feb. 2019. doi: https://doi.org/10.32771/inajog.v7i1.817.
Section
Research Article