Human Papilloma Virus16 and 18 Infection and the Cervical Cytology Changes in Combined Hormonal Contraceptive Users

Infeksi Human Papilloma Virus Tipe 16 dan 18 dan Perubahan Sitologi Serviks pada Akseptor Kontrasepsi Hormonal Kombinasi

  • Merdyana Darkuthni Faculty of Medicine Universitas Hasanuddin/ Dr. Wahidin Sudirohusodo Hospital Makassar
  • Mardiah Tahir Faculty of Medicine Universitas Hasanuddin/ Dr. Wahidin Sudirohusodo Hospital Makassar
  • Josephine L Tumedia Faculty of Medicine Universitas Hasanuddin/ Dr. Wahidin Sudirohusodo Hospital Makassar

Abstract

 
 
Objective: To evaluate the correlation between HPV-16 and 18infection and the cervical cytology changes among combinationhormonal contraceptives users.
 
Methods: A cross-sectional study involved 40 women usingcombined hormonal contraceptive (oral or injection/DMPA contraceptive)and 40 women of non-hormonal contraceptive users wasconducted in Dr. Wahidin Sudirohusodo hospital, some affiliatedhospitals of Department of Obstetrics and Gynecology Faculty ofMedicine, Universitas Hasanuddin and a private clinic in Makassarfrom November 2015 and April 2016. HPV 16 and 18 genotypingin cervix using PCR method and cervical cytology changes usingliquid-based cytology (LBC) method were performed. HPV infectionand cervical cytology changes were analysis based on Fisher’s testand chi-square test.
 
Results: A significant difference found only in parity (p<0.05)between users and control of baseline characteristics. Neither usersnor control were significantly associated with HPV-16 and 18infection and changes in cervical cytology.
 
Conclusion: Combined hormonal contraceptives are not correlatedwith HPV-16 and 18 infection and changes in cervical cytology.
Keywords: cervix, combined hormonal contraceptive, human papillomavirus

Author Biographies

Merdyana Darkuthni, Faculty of Medicine Universitas Hasanuddin/ Dr. Wahidin Sudirohusodo Hospital Makassar
Department of Obstetrics and Gynecology
Mardiah Tahir, Faculty of Medicine Universitas Hasanuddin/ Dr. Wahidin Sudirohusodo Hospital Makassar
Department of Obstetrics and Gynecology
Josephine L Tumedia, Faculty of Medicine Universitas Hasanuddin/ Dr. Wahidin Sudirohusodo Hospital Makassar
Department of Obstetrics and Gynecology
Published
2018-09-04
How to Cite
DARKUTHNI, Merdyana; TAHIR, Mardiah; TUMEDIA, Josephine L. Human Papilloma Virus16 and 18 Infection and the Cervical Cytology Changes in Combined Hormonal Contraceptive Users. Indonesian Journal of Obstetrics and Gynecology, [S.l.], p. 188 - 192, sep. 2018. ISSN 2338-7335. Available at: <http://inajog.com/index.php/journal/article/view/785>. Date accessed: 23 oct. 2018. doi: https://doi.org/10.32771/inajog.v6i3.785.
Section
Research Article