Malondialdehyde Levels in Preeclampsia before and after Delivery

Kadar Malondialdehid pada Penderita Preeklamsia Berat sebelum dan sesudah Persalinan

  • Harold Rumopa Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manado
  • Freddy W. Wagey Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manado
  • Eddy Suparman Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manado

Abstract

 

Objective: Determine differences plasma levels MDA in preeclampsia
before and 2 hours after delivery.

 

Methods: This was an analytic cross-sectional study. Subject
consists of 23 pregnancies with preeclampsia, where 23 blood
samples taken before delivery and 23 were taken 2 hours after
delivery. This study was conducted from August 2016 until
December 2016 at Department of Obstetrics and Gynecology
Faculty of Medicine Universitas Sam Ratulangi / Prof. Dr. R. D.
Kandou Hospital Manado and satellite hospital. Samples were
taken from plasma and analysed using HPLC method at Prodia
clinical laboratory.

 

Results: In patients with severe preeclampsia before delivery
we found average value (1.4796  0.40819 nmol/ml), minimum
value (1.03 nmol/ml) and maximal value (2.77 nmol/ml)
and 2 hours after delivery with average value (1.2470 
0.34324 nmol/ml), minimum value (0.91 nmol/ml), and maximum
value (2.47 nmol/ml). by using Wilcoxon test, we found
there were significant differences in plasma levels of MDA (p =
0.000).

 

Conclusion: This significant difference suggests that decreased
plasma levels of MDA 2 hours after delivery and gives the sense that
there is a relationship between oxidative stress of cells with severe
preeclampsia before and shortly after delivery, that MDA is an indicator
of oxidative stress.

 

Keywords: malondialdehyde, oxidative stress, peroxidation lipid,
preeclampsia

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Author Biographies

Harold Rumopa, Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manado

Department of Obstetrics and Gynecology

 

Freddy W. Wagey, Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manado

Department of Obstetrics and Gynecology

Eddy Suparman, Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manado

Department of Obstetrics and Gynecology

Published
2018-07-25
Section
Research Article