Malondialdehyde Levels in Preeclampsia before and after Delivery

Kadar Malondialdehid pada Penderita Preeklamsia Berat sebelum dan sesudah Persalinan

  • Harold Rumopa Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manado
  • Freddy W. Wagey Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manado
  • Eddy Suparman Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manado

Abstract

 
Objective: Determine differences plasma levels MDA in preeclampsiabefore and 2 hours after delivery.
 
Methods: This was an analytic cross-sectional study. Subjectconsists of 23 pregnancies with preeclampsia, where 23 bloodsamples taken before delivery and 23 were taken 2 hours afterdelivery. This study was conducted from August 2016 untilDecember 2016 at Department of Obstetrics and GynecologyFaculty of Medicine Universitas Sam Ratulangi / Prof. Dr. R. D.Kandou Hospital Manado and satellite hospital. Samples weretaken from plasma and analysed using HPLC method at Prodiaclinical laboratory.
 
Results: In patients with severe preeclampsia before deliverywe found average value (1.4796  0.40819 nmol/ml), minimumvalue (1.03 nmol/ml) and maximal value (2.77 nmol/ml)and 2 hours after delivery with average value (1.2470 0.34324 nmol/ml), minimum value (0.91 nmol/ml), and maximumvalue (2.47 nmol/ml). by using Wilcoxon test, we foundthere were significant differences in plasma levels of MDA (p =0.000).
 
Conclusion: This significant difference suggests that decreasedplasma levels of MDA 2 hours after delivery and gives the sense thatthere is a relationship between oxidative stress of cells with severepreeclampsia before and shortly after delivery, that MDA is an indicatorof oxidative stress.
 
Keywords: malondialdehyde, oxidative stress, peroxidation lipid,preeclampsia

Author Biographies

Harold Rumopa, Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manado
Department of Obstetrics and Gynecology  
Freddy W. Wagey, Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manado
Department of Obstetrics and Gynecology
Eddy Suparman, Faculty of Medicine Universitas Sam Ratulangi Prof. Dr. R.D. Kandou Hospital Manado
Department of Obstetrics and Gynecology
How to Cite
RUMOPA, Harold; WAGEY, Freddy W.; SUPARMAN, Eddy. Malondialdehyde Levels in Preeclampsia before and after Delivery. Indonesian Journal of Obstetrics and Gynecology, [S.l.], p. 143 - 148, sep. 2018. ISSN 2338-7335. Available at: <http://inajog.com/index.php/journal/article/view/777>. Date accessed: 23 oct. 2018. doi: https://doi.org/10.32771/inajog.v6i3.777.
Section
Research Article