Malondialdehyde Levels in Preeclampsia before and after Delivery
Kadar Malondialdehid pada Penderita Preeklamsia Berat sebelum dan sesudah Persalinan
Objective: Determine differences plasma levels MDA in preeclampsiabefore and 2 hours after delivery.
Methods: This was an analytic cross-sectional study. Subjectconsists of 23 pregnancies with preeclampsia, where 23 bloodsamples taken before delivery and 23 were taken 2 hours afterdelivery. This study was conducted from August 2016 untilDecember 2016 at Department of Obstetrics and GynecologyFaculty of Medicine Universitas Sam Ratulangi / Prof. Dr. R. D.Kandou Hospital Manado and satellite hospital. Samples weretaken from plasma and analysed using HPLC method at Prodiaclinical laboratory.
Results: In patients with severe preeclampsia before deliverywe found average value (1.4796 0.40819 nmol/ml), minimumvalue (1.03 nmol/ml) and maximal value (2.77 nmol/ml)and 2 hours after delivery with average value (1.2470 0.34324 nmol/ml), minimum value (0.91 nmol/ml), and maximumvalue (2.47 nmol/ml). by using Wilcoxon test, we foundthere were significant differences in plasma levels of MDA (p =0.000).
Conclusion: This significant difference suggests that decreasedplasma levels of MDA 2 hours after delivery and gives the sense thatthere is a relationship between oxidative stress of cells with severepreeclampsia before and shortly after delivery, that MDA is an indicatorof oxidative stress.
Keywords: malondialdehyde, oxidative stress, peroxidation lipid,preeclampsia
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How to Cite
RUMOPA, Harold; WAGEY, Freddy W.; SUPARMAN, Eddy. Malondialdehyde Levels in Preeclampsia before and after Delivery. Indonesian Journal of Obstetrics and Gynecology, [S.l.], p. 143 - 148, july 2018. ISSN 2338-7335. Available at: <http://inajog.com/index.php/journal/article/view/777>. Date accessed: 22 feb. 2019. doi: https://doi.org/10.32771/inajog.v6i3.777.