Malondialdehyde Levels in Preeclampsia before and after Delivery

Kadar Malondialdehid pada Penderita Preeklamsia Berat sebelum dan sesudah Persalinan

Abstract

Objective: Determine differences plasma levels MDA in preeclampsia
before and 2 hours after delivery.

Methods: This was an analytic cross-sectional study. Subject
consists of 23 pregnancies with preeclampsia, where 23 blood
samples taken before delivery and 23 were taken 2 hours after
delivery. This study was conducted from August 2016 until
December 2016 at Department of Obstetrics and Gynecology
Faculty of Medicine Universitas Sam Ratulangi / Prof. Dr. R. D.
Kandou Hospital Manado and satellite hospital. Samples were
taken from plasma and analysed using HPLC method at Prodia
clinical laboratory.

Results: In patients with severe preeclampsia before delivery
we found average value (1.4796  0.40819 nmol/ml), minimum
value (1.03 nmol/ml) and maximal value (2.77 nmol/ml)
and 2 hours after delivery with average value (1.2470 
0.34324 nmol/ml), minimum value (0.91 nmol/ml), and maximum
value (2.47 nmol/ml). by using Wilcoxon test, we found
there were significant differences in plasma levels of MDA (p =
0.000).

Conclusion: This significant difference suggests that decreased
plasma levels of MDA 2 hours after delivery and gives the sense that
there is a relationship between oxidative stress of cells with severe
preeclampsia before and shortly after delivery, that MDA is an indicator
of oxidative stress.

Keywords: malondialdehyde, oxidative stress, peroxidation lipid,
preeclampsia