Heat Shock Protein 70 (HSP 70) Level in Threatened Abortion

Abstract

Objective: To determine the level of Heat Shock Protein 70 (HSP 70) in threatened abortion compared with normal pregnancy. Method: This was a cross-sectional analytic study design conducted to examine the HSP 70 level on 25 subjects of pregnant women with <20 weeks of gestation and 30 subjects with threatened abortion. It was held at Obstetrics outpatient clinic Prof. dr. RD Kandou Manado Hospital. The data obtained were analyzed using SPSS software version 22.0 and we did the discussion using the existing literature theory. Result: The statistical analysis using the Mann-Whitney test showed that there were significant differences of median level of HSP 70 between threatened abortion group and normal pregnancy with less than 20 week of gestation (p<0.001). Conclusion: Heat Shock Protein 70 can be a marker to predict the risk of miscarriage in the first trimester of pregnancy. Keywords: HSP 70, pregnancy, threatened abortion